Treatment Of Migraine

Treatment Of Migraine

Migraine is a chronic disorder characterized by recurrent moderate to severe headaches often in association with a number of autonomic nervous system symptoms. 
Typically the headache is unilateral (affecting one half of the head) and pulsating in nature, lasting from 2 to 72 hours. Associated symptoms may include nausea, vomiting, photophobia (increased sensitivity to light), phonophobia (increased sensitivity to sound) and the pain is generally aggravated by physical activity. Up to one-third of people with migraine headaches perceive an aura: a transient visual, sensory, language, or motor disturbance which signals that the headache will soon occur.
Migraines are believed to be due to a mixture of environmental and genetic factors. About two-thirds of cases run in families. Fluctuating hormone levels may also play a role: migraine affects slightly more boys than girls before puberty, but about two to three times more women than men. Propensity for migraines usually decreases during pregnancy. The exact mechanisms of migraines are not known. It is, however, believed to be a neurovascular disorder.The primary theory is related to increased excitability of the cerebral cortex and abnormal control of pain neurons in the trigeminal nucleus of the brainstem

Drug Used In Migraine

A.Drug used for acute migraine headache:

1.Nsaid

-paracetamol

-aspirin

-diclofenac

-ibuprofen

-naproxen

2.Antiemetic

-domperidone

-metoclopramide

3.5HT1 Agonists

-sumatriptan

-rizatriptan

-zolmitriptan

-almotripton

-frovatriptan

4.Ergot alkaloid

-ergotamine

B.Drug For Prophylaxis of Migraine

1.Anti histamine n 5HT antagonist
-pizotifen

2.Beta blocker

-propranolol

3.Tricyclic anti depressant

-amitriptyline

4.Both calcium and sodium chanel blocker

-flunarizine

5.Other drugs:

-Valproic acid

-Methysergide

-Gabapentin

-Calcium  channel blockers

• Verapmil
• nifedipine

by Lakdhes..