How To Manage Bleeding Disorder :

How To Manage Bleeding Disorder :

Thromboembolism

Thrombosis  is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets (thrombocytes) and fibrin to form a blood clot to prevent blood loss. Alternatively, even when a blood vessel is not injured, blood clots may form in the body if the proper conditions present themselves. If the clotting is too severe and the clot breaks free, the traveling clot is now known as an embolus.

Thromboembolism is the combination of thrombosis and its main complication, embolism.When a thrombus occupies more than 75% of cross-sectional area of the lumen of an artery, blood flow to the tissue supplied is reduced enough to cause symptoms because of decreased oxygen (hypoxia) and accumulation of metabolic products like lactic acid. More than 90% obstruction can result in anoxia, the complete deprivation of oxygen, and infarction, a mode of cell death.

  

Treatment For Bleeding Disorder:

Anti Platelet Drugs

Classification:

1.Cyclooxygenase inhibitor

-Aspirin

2.Adenosine diphosphate  receptor inhibitor

-Clopidogrel

-Prasugrel

-Ticlopidine

3.Gylcoprotein inhibitor

-Abciximab

-Eptifibatide

-Tirofiban

4.Diphosphoesterase inhibitor

-Cilostazol

5.Adenosine reuptake inhibitor

-Dipyridamole

Fibrinolytic/Thrombolytic Drug

1.Streptokinase

2.Urokinase

3.Alteplase

4.Reteplase

5.Tenecteplase

6.Tissue plasminogen activator

Anti Fibrinolytic

1.Aminocaproic acid

2.Tranexamic acid

3.Protamine sulfate

4.Vitamin k

5.Aprotinin

Anticoagulant Drug

 Used In Vivo

A.Parenteral  Anticoagulant Drugs:

a)Indirect Thrombin Inhibitor:

1.Regular Heparin/Standard Heparin

2.Low molecular weight /irregular heparin

-Tinzaparin

-Pamparin

-Dalteparin

-Nadroparin

-Ardeparin

-Enoxaparin

-Reviparin

3.Synthetic Pentasaccharide

-Fondaparinux

b.Direct Thrombin Inhibitor

-Hirudin

-Argatroban

-Bivalirudin

-Melagatran

-Ximelagatran

B.Oral Anticoagulant Drug

-.warfarin

-Dicoumarol

Used in Vitro

a.Heparin

b.Calcium chelating agent

1.3.8 % Na Citrate

2.Na Oxalate

by Lakdhes..