Lipid Lowering Drugs

How To Manage Obesity 

Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems. People are considered as obese when their body mass index (BMI), a measurement obtained by dividing a person's weight in kilograms by the square of the person's height in metres, exceeds 30 kg/m2.

Obesity increases the likelihood of various diseases, particularly heart disease, type 2 diabetes, obstructive sleep apnea, cert.in types of cancer, osteoarthritis and asthma. Obesity is most commonly caused by a combination of excessive food energy intake, lack of physical activity, and genetic susceptibility, although a few cases are caused primarily by genes, endocrine disorders, medications or psychiatric illness. Evidence to support the view that some obese people eat little yet gain weight due to a slow metabolism is limited; on average obese people have a greater energy expenditure than their thin counterparts due to the energy required to maintain an increased body mass.

Dieting and physical exercise are the mainstays of treatment for obesity. Diet quality can be improved by reducing the consumption of energy-dense foods such as those high in fat and sugars, and by increasing the intake of dietary fiber. If diet, exercise and medication are not effective, a gastric balloon may assist with weight loss, or surgery may be performed to reduce stomach volume and/or bowel length, leading to earlier satiation and reduced ability to absorb nutrients from food.Anti-obesity drugs may be taken to reduce appetite or inhibit fat absorption together with a suitable diet.Those are:

Lipid lowering

A.Predominantly Cholesterol Lowering Agent

1.HMG CoA Reductase Inhibitor( statin)

-Atorvastatin

-Pravastatin

-Simvastatin

-Fluvastatin

-Rosuvastatin

2.Cholestrol absoprtion inhibitor

-Ezetimibe

3.Bile salt sequestering inhibitor

-Cholestyramine

-Colestipol

-Colesevelam

4.Nicotinic Acid(Vit.B3)

B.Predominantly TG Lowering Agent:

1.Fibrate derivatives:

-Phenofibrate

-Bezafibrate

-Ciprofibrate

-Gemfibrozil

2.Highly poly unsaturated long chain n-3 fatty acid:

-Eicosapentanoic acid

-Docosahexanoic acid

by Lakdhes